Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4204 |
| PDBID: | 7LUC |
| Chains: | LM_B |
| Organism: | Respiratory syncytial virus, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.21 |
| Reference: | 10.1016/j.immuni.2021.03.004 |
| Antibody | |
| Antibody: | 32.4K Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Respiratory syncytial virus (RSV) Fusion glycoprotein F0 |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; P13843; P03420; P11209; P13843; |
Sequence information
Antibody
Heavy Chain: L
Mutation: NULL
| >7LUC_L|Chain J, L, N|32.4K Fab Heavy chain|Homo sapiens (9606) EVQLVQSGAEVKKPGESLKISCKGSADSFTNHWIGWVRQTPGKGLEWMGMIYPGDSDTRYSPSFQGQVTLSVDKSVTTVYLQWNSLKASDTAIYYCARQVGGVVVAEPPPYYYYGMDAWGQGTTVTVSS |
Light Chain: M
Mutation: NULL
| >7LUC_M|Chain K, M, O|32.4K Fab Light chain|Homo sapiens (9606) DIQLTQSPSSLSASVGDRVTLTCRASQSIATFLNWFQQRPGKAPKLLMFDASKLQTGVPSRFSGSGSGTHFTLTISTLQPEDFATYYCQQSYDLPLTFGPGTKVEIK |
Antigen
Chain: B
Mutation: NULL
| >7LUC_B|Chain A, B, C|Fusion glycoprotein F0|Respiratory syncytial virus (12814) QNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKEIKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGSLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition L: THR30 ASN31 HIS32 TRP33 GLY53 ASP54 ASP56 ARG58 LYS73 VAL96 GLY97 GLY98 VAL99 M: PHE32 PHE49 ASP50 LYS53 B: SER62 ASN63 ILE64 LYS65 GLU66 ILE67 LYS68 CYS69 ASN70 GLY71 LEU83 ASP200 LEU204 PRO205 VAL207 ASN208 LYS209 SER211 CYS212 GLU294 GLU295 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
