Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4202 |
| PDBID: | 7LUC |
| Chains: | HI_B |
| Organism: | Respiratory syncytial virus, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.21 |
| Reference: | 10.1016/j.immuni.2021.03.004 |
| Antibody | |
| Antibody: | 01.4B Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Respiratory syncytial virus (RSV) Fusion glycoprotein F0 |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; P13843; P03420; P11209; P13843; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7LUC_H|Chain D, F, H|01.4B Fab Heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKLSCQASGYTFNNYGVSWLRQAPGQGLEWMGWISAYNGNKKYAPKFQGRLTLTTVTSTGTAYMELRSLKSDDTALYFCARDPPAVAAAMFDFWGQGTQVTVSS |
Light Chain: I
Mutation: NULL
| >7LUC_I|Chain E, G, I|01.4B Fab Light chain|Homo sapiens (9606) DVVLTQSPLSLPVTLGQPASISCRSSQSLVLSDGNTYLSWFHQRPGHSPRRLIYRISHRDSGVPDRFSGSESGTDFTLKISRVEAEDVGIYYCMQGTHWPRTFGQGTKVEIK |
Antigen
Chain: B
Mutation: NULL
| >7LUC_B|Chain A, B, C|Fusion glycoprotein F0|Respiratory syncytial virus (12814) QNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKEIKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGSLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: THR28 ASN31 TYR32 TYR53 ASN54 ASN56 PRO96 PRO97 ALA98 VAL99 I: SER27 ASP28 GLY29 ASN30 THR31 TYR32 ARG46 TYR49 ARG50 ILE51 HIS53 B: TYR53 GLU60 ALA170 LEU172 SER173 THR174 ASN175 LYS176 ALA177 VAL178 SER180 SER186 LEU188 LYS191 VAL192 LEU193 ASP194 ASN197 LYS201 LYS226 GLU256 SER259 ASN262 ASP263 MET264 PRO265 ILE266 LYS271 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
