Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4197 |
| PDBID: | 7LSF |
| Chains: | HL_E |
| Organism: | Homo sapiens, Tick-borne encephalitis virus (WESTERN SUBTYPE) |
| Method: | XRD |
| Resolution (Å): | 2.24 |
| Reference: | 10.1084/jem.20210236 |
| Antibody | |
| Antibody: | T025 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tick-borne encephalitis virus (TBEV) Envelope protein E (Western Subtype) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7LSF_H|Chain A[auth H]|T025 Fab Heavy Chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGMHWVRQAPGKGLDWVAVISYDAISKSYADSVEGRFTISRDNSKNTLYLQMNSLRAEDSAVYYCAKSPTAIDPPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: L
Mutation: NULL
| >7LSF_L|Chain B[auth L]|T025 Fab Light Chain|Homo sapiens (9606) EIVMTQSPATLSVSPGERATLSCWASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSASGSGTEFTLTISSLQSEDFAVYYCQQYNNWPPRFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >7LSF_E|Chain C[auth E]|Envelope protein E|Tick-borne encephalitis virus (WESTERN SUBTYPE) (11088) MKGLTYTMCDKTKFTWKRAPTDSGHDTVVMEVTFSGTKPCRIPVRAVAHGSPDVNVAMLITPNPTIENNGGGFIEMQLPPGDNIIYVGELSHQWFQKGSHHHHHHGLNDIFEAQKIEWHE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: ASN31 TYR52 ILE55 SER56 LYS57 SER58 THR97 ALA98 ILE99 L: GLN27 SER30 ASN32 TYR91 ASN92 ASN93 TRP94 PRO96 E: THR305 MET306 ASP308 LYS309 THR310 LYS311 SER333 GLY334 THR335 LYS336 PRO337 CYS338 ARG339 ASN366 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
