Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4130 |
| PDBID: | 7LFB |
| Chains: | HL_X |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.91 |
| Reference: | 10.1038/s42003-021-02387-5 |
| Antibody | |
| Antibody: | 7D6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Apolipoprotein L1 |
| Antigen mutation: | No |
| Durg Target: | O14791 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7LFB_H|Chain A[auth H]|Fab 7D6 heavy chain|Homo sapiens (9606) QIQLVQSGPDLKKPGETVKISCRTSGYAFTNYGVNWVKQAPGKGLKWMGWINTNTGQTTYAEEFRGRFAISLETSASTAFLTISNLKNEDSATYFCARLIYDGDYISSDFWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD |
Light Chain: L
Mutation: NULL
| >7LFB_L|Chain B[auth L]|Fab 7D6 light chain|Homo sapiens (9606) DIQMTQSPDSLSASVGETVTITCGASENIYGALNWYQRKQGKSPQLLIYGATNLADGMSSRFSGSRSGRQYSLKISSLHPDDVATYYCQNALSMPYTFGGGTNLETKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: X
Mutation: NULL
| >7LFB_X|Chain C[auth X]|Apolipoprotein L1|Homo sapiens (9606) MDYKDDDDKGENLYFQGSDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: THR30 ASN31 TYR32 GLY33 TRP50 ASN52 THR53 ASN54 GLN57 THR59 LEU99 ILE100 TYR101 ASP102 GLY103 ASP104 TYR105 ILE106 L: ILE2 GLU27 ASN28 TYR30 ALA32 ARG66 LEU92 SER93 MET94 TYR96 X: GLU152 ILE155 ARG156 ARG157 ARG159 ALA160 ALA162 ASP163 GLY164 VAL165 GLN166 LYS167 VAL168 HIS169 LYS170 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
