Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4129 |
| PDBID: | 7LFA |
| Chains: | HL_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.86 |
| Reference: | 10.1038/s42003-021-02387-5 |
| Antibody | |
| Antibody: | 3B6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Apolipoprotein L1 |
| Antigen mutation: | No |
| Durg Target: | O14791 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7LFA_H|Chain B, E[auth H]|Fab 3B6 heavy chain|Homo sapiens (9606) QVQLQQSGAELARPGASVKLSCKASGYTFTSHWMQWLKQRPGQGLEWIGAIYPGDGDTKFTQKFKDKATLTADKSSTTAYMQLSSLASEDSAVYYCARENLYGYYFDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD |
Light Chain: L
Mutation: NULL
| >7LFA_L|Chain D, F[auth L]|Fab 3B6 light chain|Homo sapiens (9606) QAVVTQESALTTSPGETVTLTCRSSTGAVTSGNFANWVQEKPDHLFTGLIGGADNRAPGVPARFSGSLIGDKAALIITGAQTEDEAIYFCALWYSDHWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: C
Mutation: NULL
| >7LFA_C|Chain A, C|Apolipoprotein L1|Homo sapiens (9606) MDYKDDDDKGENLYFQGSDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: TRP33 TYR52 ASP55 ASP57 LYS59 GLU99 LEU101 TYR102 TYR104 L: THR30 SER31 GLY32 PHE34 GLY52 ASP54 ASN55 TRP93 SER95 TRP98 C: ILE123 MET124 LYS125 ASP126 LYS127 ASN128 HIS130 LYS132 GLY133 GLN134 ARG137 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
