Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4079 |
| PDBID: | 7LCV |
| Chains: | AB_C |
| Organism: | Homo sapiens, Neisseria meningitidis |
| Method: | XRD |
| Resolution (Å): | 1.70 |
| Reference: | 10.1371/journal.ppat.1009655 |
| Antibody | |
| Antibody: | 1A3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Factor H binding protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7LCV_A|Chain A|Immunoglobulin heavy chain Fd fragment|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSSHYTDSVKGRFTISRDNSKNTLWLQMNSLRAEDTAIYYCAKTSGSYYYHYEIDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: B
Mutation: NULL
| >7LCV_B|Chain B|Immunoglobulin kappa light chain|Homo sapiens (9606) AEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSNRATGIPDRFSGSGSGTDFTLTVSRLEPEDFAVYYCQQYGSSPCSFGQGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS |
Antigen
Chain: C
Mutation: NULL
| >7LCV_C|Chain C|Factor H binding protein|Neisseria meningitidis (487) CSSGGGGVAADIGAGLADALTAPLDHKDKGLQSLTLDQSVRKNEKLKLAAQGAEKTYGNGDSLNTGKLKNDKVSRFDFIRQIEVDGQLITLESGEFQVYKQSHSALTAFQTEQIQDSEHSGKMVAKRQFRIGDIAGEHTSFDKLPEGGRATYRGTAFGSDDAGGKLTYTIDFAAKQGNGKIEHLKSPELNVDLAAADIKPDGKRHAVISGSVLYNQAEKGSYSLGIFGGKAQEVAGSAEVKTVNGIRHIGLAAKQLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: THR28 SER30 SER31 TYR32 SER52 SER54 GLY56 SER57 SER58 SER100 GLY101 SER102 TYR103 TYR104 TYR105 HIS106 TYR107 B: SER29 VAL30 SER31 SER32 SER33 TYR34 TYR51 ASN55 SER69 GLY70 C: LYS47 ALA49 ALA50 GLN51 GLY52 ALA53 GLU54 ARG75 ASP77 PHE78 ILE79 GLN81 GLN87 LEU88 ILE89 THR90 SER93 GLY94 GLU95 GLU112 GLN113 GLY121 LYS122 MET123 ALA125 ARG127 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
