Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4058 |
| PDBID: | 7L8S |
| Chains: | HL_A |
| Organism: | Human immunodeficiency virus 1, Macaca mulatta |
| Method: | EM |
| Resolution (Å): | 4.30 |
| Reference: | 10.1038/s41467-021-25087-4 |
| Antibody | |
| Antibody: | pAbC-4 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 SOSIP.v5.2(7S) gp120 |
| Antigen mutation: | No |
| Durg Target: | P00750 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7L8S_H|Chain G[auth H]|Rh.33172 pAbC-4 - Heavy Chain|Macaca mulatta (9544) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Light Chain: L
Mutation: NULL
| >7L8S_L|Chain H[auth L]|Rh.33172 pAbC-4 - Light Chain|Macaca mulatta (9544) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Antigen
Chain: A
Mutation: NULL
| >7L8S_A|Chain A, C, E|BG505 SOSIP.v5.2(7S) - gp120|Human immunodeficiency virus 1 (11676) MKRGLCCVLLLCGAVFVSPSQEIHARFRRGARAENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHCCVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCTNVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNESVQINCTRPNNNTVKSIRIGPGQWFYYTGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: UNK30 UNK31 UNK32 UNK33 UNK52 UNK53 UNK54 UNK55 UNK56 UNK96 UNK97 UNK98 UNK99 UNK100 UNK101 L: UNK29 UNK30 UNK31 UNK49 UNK90 UNK91 A: THR132 ASN133 VAL134 THR135 ASN136 ASN137 ILE138 THR139 ASP140 ARG151 ASN156 SER187 ASN188 LYS189 ASP325 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
