Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4055 |
| PDBID: | 7L8B |
| Chains: | HL_A |
| Organism: | Human immunodeficiency virus 1, Macaca mulatta |
| Method: | EM |
| Resolution (Å): | 3.70 |
| Reference: | 10.1038/s41467-021-25087-4 |
| Antibody | |
| Antibody: | pAbC-2 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 SOSIP MD39 gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7L8B_H|Chain G[auth H]|Rh.33104 pAbC-2 - Heavy Chain|Macaca mulatta (9544) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Light Chain: L
Mutation: NULL
| >7L8B_L|Chain H[auth L]|Rh.33104 pAbC-2 - Light Chain|Macaca mulatta (9544) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Antigen
Chain: A
Mutation: NULL
| >7L8B_A|Chain A, C, E|BG505 SOSIP MD39 - gp120|Human immunodeficiency virus 1 (11676) NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYTGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: UNK31 UNK32 UNK33 UNK54 UNK57 UNK58 UNK59 UNK102 UNK103 UNK104 UNK105 UNK106 L: UNK55 UNK56 UNK57 UNK58 UNK60 UNK61 UNK62 UNK99 A: ASN80 GLN82 GLU83 HIS85 GLU87 LYS229 ASP230 LYS231 LYS232 PRO238 PRO240 SER241 GLU268 GLU269 LYS351 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
