Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4054 |
| PDBID: | 7L8A |
| Chains: | HL_A |
| Organism: | Human immunodeficiency virus 1, Macaca mulatta |
| Method: | EM |
| Resolution (Å): | 3.30 |
| Reference: | 10.1038/s41467-021-25087-4 |
| Antibody | |
| Antibody: | pAbC-1 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 SOSIP MD39 gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7L8A_H|Chain C[auth H]|Rh.33104 pAbC-1 - Heavy Chain|Macaca mulatta (9544) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Light Chain: L
Mutation: NULL
| >7L8A_L|Chain D[auth L]|Rh.33104 pAbC-1 - Light Chain|Macaca mulatta (9544) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Antigen
Chain: A
Mutation: NULL
| >7L8A_A|Chain A, E[auth C], G[auth E]|BG505 SOSIP MD39 - gp120|Human immunodeficiency virus 1 (11676) NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYTGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: UNK28 UNK29 UNK31 UNK32 UNK33 UNK34 UNK53 UNK55 UNK56 UNK58 UNK100 UNK101 UNK102 UNK103 UNK105 L: UNK30 UNK31 UNK49 UNK50 UNK52 UNK53 UNK54 UNK55 UNK56 UNK57 UNK58 UNK62 UNK64 A: LYS231 GLU267 GLU268 GLU269 ASN289 THR290 GLU340 LYS344 LYS347 GLN348 ARG350 LYS351 GLY354 ASN355 ASN356 SER397 ASN398 THR399 SER400 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
