Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4051 |
| PDBID: | 7L87 |
| Chains: | HL_A |
| Organism: | Macaca mulatta, Human immunodeficiency virus 1 |
| Method: | EM |
| Resolution (Å): | 3.60 |
| Reference: | 10.1038/s41467-021-25087-4 |
| Antibody | |
| Antibody: | pAbC-2 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 SOSIP MD39 gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7L87_H|Chain A[auth H]|Rh.32034 pAbC-2 - Heavy Chain|Macaca mulatta (9544) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Light Chain: L
Mutation: NULL
| >7L87_L|Chain B[auth L]|Rh.32034 pAbC-2 - Light Chain|Macaca mulatta (9544) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Antigen
Chain: A
Mutation: NULL
| >7L87_A|Chain C[auth A], E[auth C], G[auth D]|BG505 SOSIP MD39 - gp120|Human immunodeficiency virus 1 (11676) MGILPSPGMPALLSLVSLLMGCVAETGAENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHCCVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQWFYYTGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: UNK28 UNK30 UNK31 UNK32 UNK56 UNK57 UNK58 UNK59 UNK60 UNK104 UNK105 UNK106 UNK107 L: UNK30 UNK31 UNK32 UNK33 UNK51 UNK52 UNK53 UNK68 UNK69 UNK92 A: ASN80 PRO81 GLU83 ILE84 HIS85 GLU87 LYS227 LYS229 LYS231 LYS232 LEU265 ALA266 GLU267 GLU268 GLU269 ASN289 THR290 GLU340 LYS344 LYS347 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
