Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4050 |
| PDBID: | 7L86 |
| Chains: | HL_A |
| Organism: | Macaca mulatta, Human immunodeficiency virus 1 |
| Method: | EM |
| Resolution (Å): | 3.40 |
| Reference: | 10.1038/s41467-021-25087-4 |
| Antibody | |
| Antibody: | pAbC-1 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 SOSIP MD39 gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7L86_H|Chain A[auth H]|Rh.32034 pAbC-1 - Heavy Chain|Macaca mulatta (9544) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Light Chain: L
Mutation: NULL
| >7L86_L|Chain B[auth L]|Rh.32034 pAbC-1 - Light Chain|Macaca mulatta (9544) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX |
Antigen
Chain: A
Mutation: NULL
| >7L86_A|Chain C[auth A], E[auth C], G[auth E]|BG505 SOSIP MD39 - gp120|Human immunodeficiency virus 1 (11676) MGILPSPGMPALLSLVSLLMGCVAETGAENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHCCVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQWFYYTGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: UNK33 UNK56 UNK98 UNK99 UNK100 UNK101 UNK103 UNK104 UNK105 UNK106 UNK107 UNK108 L: UNK29 UNK30 UNK48 UNK49 UNK67 UNK91 UNK92 UNK93 UNK94 UNK95 A: THR278 HIS352 PHE353 GLY354 ASN355 ASN356 THR357 ILE358 ILE396 GLY459 THR461 ASN462 SER463 THR464 THR465 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
