Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4049 |
| PDBID: | 7L7R |
| Chains: | DC_G |
| Organism: | Homo sapiens, Crimean-Congo hemorrhagic fever virus strain IbAr10200 |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1126/science.abl6502 |
| Antibody | |
| Antibody: | ADI-37801 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | The Crimean-Congo hemorrhagic fever virus (CCHFV) membrane fusion glycoprotein C |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >7L7R_D|Chain D|ADI-37801 Fab heavy chain|Homo sapiens (9606) QVQLVESGPGLLKPSQTLSLTCTVSGGSLSSGGYYWSWIRQHPGQGLECIGYIYYSGSTYYSPSLESRVDISMDTSMNQFSLKLRSVTAADTAVYYCARDRMDYSGSGVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKGLEVLFQ |
Light Chain: C
Mutation: NULL
| >7L7R_C|Chain C|ADI-37801 Fab light chain|Homo sapiens (9606) EIVLTQSPSTLSASVGDRVTITCRASQSISRWLAWYQQKPGKAPRLLIHKASSLESGVPSRFSGSGSGTEFTLTITSLQPDDFATYYCQQYGSYSRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: G
Mutation: NULL
| >7L7R_G|Chain E[auth G]|Glycoprotein C|Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (652961) FLDSTAKGMKNLLNSTSLETSLSIEAPWGAINVQSTYKPTVSTANIALSWSSVEHRGNKILVSGRSESIMKLEERTGISWDLGVEDASESKLLTVSVMDLSQMYSPVFEYLSGDRQVGEWPKATCTGDCPERCGCTSSTCLHKEWPHSRNWRCNPTWCWGVGTGCTCCGLDVKDLFTDYMFVKWKVEYIKTEAIVCVELTSQERQCSLIEAGTRFNLGPVTITLSEPRNIQQKLPPEIITLHPRIEEGFFDLMHVQKVLSASTVCKLQSCTHGVPGDLQVYHIGNLLKGDKVNGHLIHKIEPHFNTSWMSWDGCDLDYYCNMGDWPSCTYTGVTQHNHASFVNLLNIETDYTKNFHFHSKRVTAHGDTPQLDLKARPTYGAGEITVLVEVADMELHTKKIEISGLKFASLACTGCYACSSGISCKVRIHVDEPDELTVHVKSDDPDVVAASSSLMARKLEFGTDSTFKAFSAMPKTSLCFYIVEREHCKSCSEEDTKKCVNTKLEQPQSILIEHKGTIIGKQNSTCTAKASCWLESVKSGSLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: TRP32 GLY92 SER93 TYR94 D: TYR50 TYR52 TYR53 SER54 SER56 THR57 TYR58 MET97 ASP98 TYR99 G: CYS1165 THR1166 HIS1187 TRP1191 ASN1194 TRP1197 CYS1198 TRP1199 GLY1200 VAL1201 GLY1202 THR1203 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
