Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4048 |
| PDBID: | 7L7R |
| Chains: | BA_G |
| Organism: | Homo sapiens, Crimean-Congo hemorrhagic fever virus strain IbAr10200 |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1126/science.abl6502 |
| Antibody | |
| Antibody: | ADI-36121 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | The Crimean-Congo hemorrhagic fever virus (CCHFV) membrane fusion glycoprotein C |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >7L7R_B|Chain B|ADI-36121 Fab heavy chain|Homo sapiens (9606) EVQLLESGGDLVQPGGSLRLSCAASGFTFSSYVMSWVRQAPGKGLEWVSVIYRGGSTKYADSVKGRFTISRDDSKNTLYLQMNSLRVEDTAVYYCVKDPKAWLEPEWWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKGLEVLFQ |
Light Chain: A
Mutation: NULL
| >7L7R_A|Chain A|ADI-36121 Fab light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQSISKYLSWFQQKPGKAPNLLIYAASYLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSNPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: G
Mutation: NULL
| >7L7R_G|Chain E[auth G]|Glycoprotein C|Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (652961) FLDSTAKGMKNLLNSTSLETSLSIEAPWGAINVQSTYKPTVSTANIALSWSSVEHRGNKILVSGRSESIMKLEERTGISWDLGVEDASESKLLTVSVMDLSQMYSPVFEYLSGDRQVGEWPKATCTGDCPERCGCTSSTCLHKEWPHSRNWRCNPTWCWGVGTGCTCCGLDVKDLFTDYMFVKWKVEYIKTEAIVCVELTSQERQCSLIEAGTRFNLGPVTITLSEPRNIQQKLPPEIITLHPRIEEGFFDLMHVQKVLSASTVCKLQSCTHGVPGDLQVYHIGNLLKGDKVNGHLIHKIEPHFNTSWMSWDGCDLDYYCNMGDWPSCTYTGVTQHNHASFVNLLNIETDYTKNFHFHSKRVTAHGDTPQLDLKARPTYGAGEITVLVEVADMELHTKKIEISGLKFASLACTGCYACSSGISCKVRIHVDEPDELTVHVKSDDPDVVAASSSLMARKLEFGTDSTFKAFSAMPKTSLCFYIVEREHCKSCSEEDTKKCVNTKLEQPQSILIEHKGTIIGKQNSTCTAKASCWLESVKSGSLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: SER30 LYS31 TYR32 SER52 TYR53 SER91 TYR92 SER93 ASN94 B: THR28 SER31 VAL33 TYR52 ARG53 SER56 THR57 LYS58 PRO96 LYS97 ALA98 TRP99 G: MET1143 SER1145 PRO1146 VAL1147 PHE1148 GLU1149 LYS1225 GLU1227 TYR1228 ILE1229 LYS1230 GLU1232 PRO1276 GLU1277 LYS1306 LEU1307 GLN1308 SER1309 TYR1321 HIS1322 THR1346 HIS1405 THR1408 PRO1409 GLN1410 LEU1411 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
