Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4037 |
| PDBID: | 7L5J |
| Chains: | WL_B |
| Organism: | Murine norovirus 1, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.20 |
| Reference: | 10.1128/JVI.00176-21 |
| Antibody | |
| Antibody: | A6.2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Mouse Norovirus Protruding domain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: W
Mutation: NULL
| >7L5J_W|Chain D[auth W], F[auth Y]|Anti mouse norovirus mAb A6.2 Fab heavy chain|Mus musculus (10090) EVKLLESGGGLVQPGGSLKLSCAASGFDFSRYWMSWVRQAPGKGLEWIGQINPHSSTINYTPSLRDKFIISRDNAKNTLYLQMTKVRSEDTALYYCARLLRYFYALDYWGQGASVTVSSAKTTPPSVYPLAPGRAAAAASMVTLGCLVKGYFPEPVTVTWNSGSLAAGVHTFPAVLQAALYTLSSSVTVPSSSWPSETVTCNVAHPASSTKVDKKIVPRAA |
Light Chain: L
Mutation: NULL
| >7L5J_L|Chain C[auth L], E[auth X]|Anti mouse norovirus mAb A6.2 Fab light chain|Mus musculus (10090) QIVLTQSPAIMSASPGEKVTITCSASSSVSYMHWFQQKPGTSPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISRMEAEDAATYYCQQRSSYPFTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: B
Mutation: NULL
| >7L5J_B|Chain A, B|Capsid protein|Murine norovirus 1 (223997) SNATIYRMVDLPVIQPRLCTHARWPAPVYGLLVDPSLPSNPQWQNGRVHVDGTLLGTTPISGSWVSCFAAEAAYEFQSGTGEVATFTLIEQDGSAYVPGDRAAPLGYPDFSGQLEIEVQTETTKTGDKLKVTTFEMILGPTTNADQAPYQGRVFASVTAAASLDLVDGRVRAVPRSIYGFQDTIPEYNDGLLVPLAPPIGPFLPGEVLLRFRTYMRQIDTADAAAEAIDCALPQEFVSWFASNAFTVQSEALLLRYRNTLTGQLLFECKLYNEGYIALSYSGSGPLTFPTDGIFEVVSWVPRLYQLASVGSLATGRMLKQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition L: LEU45 TYR48 ALA54 SER55 W: SER30 ARG31 TYR32 TRP33 GLN50 ASN52 PRO53 HIS54 SER56 THR57 LEU99 LEU100 ARG101 TYR102 PHE103 TYR104 ASP107 B: TYR295 GLU296 PHE297 GLN298 THR301 GLY302 GLU303 SER377 VAL378 THR379 ALA380 ALA381 ALA382 SER383 LEU384 ASP385 LEU386 ASP388 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
