Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 401 |
| PDBID: | 2YPV |
| Chains: | HL_A |
| Organism: | Neisseria meningitidis MC58, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.80 |
| Reference: | 10.1073/pnas.1222845110 |
| Antibody | |
| Antibody: | 12C1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | LIPOPROTEIN |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >2YPV_H|Chain B[auth H]|FAB 12C1|MUS MUSCULUS (10090) QVQLQESGPELVKPGASVKISCKASGYSFSDYNMSWVKQSNGKSLEWIGIIDPKYGTINYNQKFKGKATLTVDQASSTAYMQLNSLTSEDSAVYYCVRDYYGSSYFDYWGQGTTLTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLCR |
Light Chain: L
Mutation: NULL
| >2YPV_L|Chain C[auth L]|FAB 12C1|MUS MUSCULUS (10090) DIVLTQSPSSIYASLGERVTLTCKASQDIHNYLNWFQQKPGKSPKTLIYRANRLVDGVPSRFSGGGSGQDYSLTISSLEFEDIGIYYCLQYDEFPPTFGGGTRLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >2YPV_A|Chain A|LIPOPROTEIN|NEISSERIA MENINGITIDIS MC58 (122586) GGGGVAADIGAGLADALTAPLDHKDKGLQSLTLDQSVRKNEKLKLAAQGAEKTYGNGDSLNTGKLKNDKVSRFDFIRQIEVDGQLITLESGEFQVYKQSHSALTAFQTEQIQDSEHSGKMVAKRQFRIGDIAGEHTSFDKLPEGGRATYRGTAFGSDDAGGKLTYTIDFAAKQGNGKIEHLKSPELNVDLAAADIKPDGKRHAVISGSVLYNQAEKGSYSLGIFGGKAQEVAGSAEVKTVNGIRHIGLAAKQL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP31 TYR32 ASN33 ILE50 ASP52 LYS54 TYR55 THR57 ILE58 ASN59 ASP99 TYR100 TYR101 GLY102 SER103 SER104 TYR105 L: GLN27 ASP28 HIS30 TYR32 ARG50 ARG53 SER67 GLY68 TYR91 ASP92 GLU93 PHE94 A: GLN38 ARG41 ILE114 LYS126 GLN128 ARG130 ILE131 TYR214 ASN215 ALA217 GLU218 LYS219 GLY220 SER221 GLU239 LYS241 THR242 VAL243 ASN244 GLY245 ILE246 HIS248 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
