Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3999 |
| PDBID: | 7KQL |
| Chains: | HL_T |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.49 |
| Reference: | 10.1172/JCI152864 |
| Antibody | |
| Antibody: | Tim3.18 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis A virus cellular receptor 2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7KQL_H|Chain A[auth H]|Tim3.18 Fab heavy chain|Homo sapiens (9606) QLQLQESGPGLVKPSETLSLTCTVSGGSISSRSYYWGWIRQPPGKGLEWIGSIYYSGFTYYQPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCATGGPYGDYAHWFEPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCGGHHHHHH |
Light Chain: L
Mutation: NULL
| >7KQL_L|Chain B[auth L]|Tim3.18 Fab light chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: T
Mutation: NULL
| >7KQL_T|Chain C[auth T]|Hepatitis A virus cellular receptor 2|Homo sapiens (9606) HHHHHHSAALEVLFQGPGSEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNDEKFNLKLVIKPA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: SER30 ARG32 SER33 TRP49 TYR54 TYR55 SER56 GLY57 PHE58 THR59 TYR60 LYS66 TYR103 GLY104 ASP105 TYR106 HIS108 L: TYR33 GLY93 SER94 SER95 ILE97 T: PRO29 VAL30 CYS31 PRO38 VAL39 PHE40 GLU41 CYS42 GLY43 ASN44 VAL45 VAL46 LEU47 ARG48 THR49 ASP50 GLU51 ASP53 ARG90 GLN92 GLY95 ILE96 MET97 ASP99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
