Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3998 |
| PDBID: | 7KQI |
| Chains: | AC_B |
| Organism: | Homo sapiens, Influenza B virus (B/Yamagata/16/1988) |
| Method: | XRD |
| Resolution (Å): | 4.20 |
| Reference: | 10.1021/acsinfecdis.0c00726 |
| Antibody | |
| Antibody: | 1209 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza B virus hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7KQI_A|Chain A|1209 Fab heavy chain|Homo sapiens (9606) ASEVQLVESGGGLVQPGRSLRLSCAASGFTFDDFTMHWVRQVPGKGLEWISSINWKGNALDYAGSVRGRFAISRDNAKNSLYLQMNSLRVEDTALYYCAKDFRSSSSMDYFYYYGMGVWGQGTTVIVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: C
Mutation: NULL
| >7KQI_C|Chain B[auth C]|1209 Fab light chain|Homo sapiens (9606) ASDIQMTQSPSSLSASVGDRVTITCQASQDIRQCLNWYQQKPGKPPKLLIYDASTLETGVPSRFSGRGSGTHFTFTISSLQAEDVATYYCQQFANVPLAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >7KQI_B|Chain C[auth B]|Hemagglutinin|Influenza B virus (416674) PLTTTPTKSHFANLKGTKTRGKLCPNCLNCTDLDVALGRPMCMGTIPSAKASILHEVRPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSTHNVINAERAPGGPYRLGTSGSCPNVTSRNGFFATMAWAVPRDNKTATNPLTVEVPYICTKGEDQITVWGFHSDDKTQMKNLYGDSNPQKFTSSANGVTTHYVSQIGDFPNQTEDGGLPQSGRIVVDYMVQKPGKTGTIVYQRGVLLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASP29 ASP30 TRP52 LYS53 GLY54 ASN55 ASN73 SER98 SER99 SER100 SER101 MET102 ASP103 TYR104 PHE105 TYR108 C: ILE28 ARG29 GLN30 CYS31 ALA91 B: PHE95 ARG136 LEU137 GLY138 THR139 SER140 GLY141 SER148 ARG149 ASN150 TRP158 VAL160 PRO161 ARG162 LYS165 GLN198 ASN201 LEU202 LEU238 PRO239 GLN240 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
