Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3996 |
| PDBID: | 7KQH |
| Chains: | HL_B |
| Organism: | Influenza B virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.50 |
| Reference: | 10.1021/acsinfecdis.0c00726 |
| Antibody | |
| Antibody: | 2365 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza B virus hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7KQH_H|Chain B[auth C], D[auth H]|2365 Fab heavy chain|Homo sapiens (9606) ASEVQLVESGGGLVQPGRSLRLSCAASGFTFDDYPMHWVRQVPGKGLEWVSSINWNGGSTDHADSVKGRFTISRDNARNSLYLEMNSLKSEDTALYYCAKDLRASSSMDYYYYSGMDVWGQGTMVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: L
Mutation: NULL
| >7KQH_L|Chain C[auth D], E[auth L]|2365 Fab light chain|Homo sapiens (9606) ASDIQMTQSPSSLSASVGDRVTITCQASQGINNYLNWYQQKPGKAPKVLIYDASNLQTGVPSRFSGSGSGTDFIFTISSLKPEDVATYYCQQYENVPITFGQGTRLDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >7KQH_B|Chain A, F[auth B]|Hemagglutinin|Influenza B virus (11520) PLTTTPTKSYFANLKGTRTRGKLCPDCLNCTDLDVALGRPMCVGTTPSAKASILHEVRPVTSGCFPIMHDRTKIRQLPNLLRGYEKIRLSTQNVIDAEKAPGGPYRLGTSGSCPNATSKIGFFATMAWAVPKDNYKNATNPLTVEVPYICTEGEDQITVWGFHSDNKIQMKSLYGDSNPQKFTSSANGVTTHYVSQIGDFPDQTEDGGLPQSGRIVVDYMMQKPGKTGTIVYQRGVLLPQKVWCASGRSKVIKGSLPLIGEADCLHEEYGGLNKSKPYYTGKHAKAIGNCPIWVKTPLK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: ASP30 ASP31 TRP52 ASN53 GLY54 GLY55 SER56 ARG71 ASP72 ASN73 ALA74 ARG97 ALA98 SER99 SER100 SER101 MET102 ASP103 TYR104 TYR105 L: TYR31 GLU91 B: PHE95 ARG136 LEU137 GLY138 THR139 SER140 GLY141 THR147 SER148 LYS149 ILE150 TRP158 VAL160 PRO161 LYS162 LYS164 GLN197 SER200 LEU201 LEU237 PRO238 GLN239 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
