Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3995 |
| PDBID: | 7KQG |
| Chains: | BC_A |
| Organism: | Influenza B virus (B/Florida/4/2006), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1021/acsinfecdis.0c00726 |
| Antibody | |
| Antibody: | 1272 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza B virus hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >7KQG_B|Chain B|1272 Fab heavy chain|Homo sapiens (9606) ASEVQLVESGGGLVQPGRSLRLSCAASGFTFDDYPMHWVRQAPGKGLEWVSTISWNGAGLAYADSVKGRFTVSRDNAKRVLYLQMSSLRPEDTALYYCAKDRVDTTSWDYYFHKSMDVWGQGTSVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: C
Mutation: NULL
| >7KQG_C|Chain C|1272 Fab light chain|Homo sapiens (9606) ASDIQMTQSPSSLSASVGDRVTITCQASQGIGNYLSWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFIIIRLQPEDIATYYCQQYDNLPLTFGGGTKVEITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7KQG_A|Chain A|Hemagglutinin|Influenza B virus (461739) PLTTTPTKSYFANLKGTRTRGKLCPDCLNCTDLDVALGRPMCVGTTPSAKASILHEVKPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSTQNVIDAEKAPGGPYRLGTSGSCPNATSKSGFFATMAWAVPKDNNKNATNPLTVEVPYICTEGEDQITVWGFHSDDKTQMKNLYGDSNPQKFTSSANGVTTHYVSQIGSFPDQTEDGGLPQSGRIVVDYMMQKPGKTGTIVYQRGVLLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: ASP30 ASP31 TRP53 ASN54 GLY55 ALA56 ASN74 ALA75 ASP99 THR100 THR101 SER102 TRP103 ASP104 TYR105 TYR106 C: TYR31 ASP91 ASN92 A: PHE95 ARG136 LEU137 GLY138 THR139 SER140 GLY141 THR147 SER148 LYS149 SER150 TRP158 VAL160 PRO161 LYS162 ASN163 ASP193 GLN197 ASN200 LEU201 LEU237 PRO238 GLN239 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
