Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3989 |
| PDBID: | 7KQ7 |
| Chains: | HL_B |
| Organism: | Rattus norvegicus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.20 |
| Reference: | 10.1080/19420862.2021.1883239 |
| Antibody | |
| Antibody: | MJ4-2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-21 receptor |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7KQ7_H|Chain A[auth H]|Antibody heavy chain|Rattus norvegicus (10116) EVQLVESGGGLVQPGRSLRLSCAASGVTFSDYHMAWVRQAPKKGLEWVATIIYDAARTYYRDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCATWQTTGTPGWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: L
Mutation: NULL
| >7KQ7_L|Chain B[auth L]|Antibody light chain|Rattus norvegicus (10116) DIQMTQSPSSLSASVGDRVTITCGASQSVSISRFNLMHWYQQKPGHQPKLLIYRASNLASGVPSRFSGSGSGTDFTLTINPLQAEDFATYYCQQSRESPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >7KQ7_B|Chain C[auth B]|Interleukin-21 receptor|Homo sapiens (9606) CPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP31 TYR32 HIS33 TRP47 THR50 ILE52 TYR53 ARG57 TYR59 TYR60 LYS65 TRP99 GLN100 THR101 THR102 GLY103 THR104 PRO105 TRP107 L: ILE31 SER32 ARG33 PHE34 LEU36 ARG54 ARG96 GLU97 SER98 B: GLN33 ASP34 GLN35 TYR36 GLU37 GLU38 ASP41 HIS68 PHE69 MET70 ASP72 ASP73 ILE74 SER76 GLU89 GLY91 SER92 PHE93 LEU94 GLU97 TYR129 MET130 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
