Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3951 |
| PDBID: | 7KI6 |
| Chains: | DC_B |
| Organism: | Henipavirus hendraense, Mus musculus |
| Method: | EM |
| Resolution (Å): | 2.80 |
| Reference: | 10.1038/s41594-021-00584-8 |
| Antibody | |
| Antibody: | 1F5 Full-length |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | henipaviruses (HNVs) fusion glycoprotein F0 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >7KI6_D|Chain C[auth D], F[auth G], I[auth H]|1F5 heavy chain|Mus musculus (10090) DVQLQESGPGLVKPSQSLSLTCSVTGYSITSDYYWNWIRQFPGNKLEWMGYVTYDGSNNYNPSLKNRISITRDSSKNQFFLKLNSVISEDTATYYCARFGSSYWAMDYWGQGTSLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK |
Light Chain: C
Mutation: NULL
| >7KI6_C|Chain B[auth C], E[auth F], H[auth L]|1F5 Fab light chain|Mus musculus (10090) QIVLTQSPAIMSASLGEAITLTCSASSSVSYMHWYQQKSGTSPKLLIYSTSNLASGVPSRFSGSGSGTFYSLTISSVEAEDAADYYCHQWYSYPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: B
Mutation: NULL
| >7KI6_B|Chain A, D[auth B], G[auth E]|Fusion glycoprotein F0|Hendra henipavirus (3052223) MATQEVRLKCLLCGIIVLVLSLEGLGILHYEKLSKIGLVKGITRKYKIKSNPLTKDIVIKMIPNVSNVSKCTGTVMENYKSRLTGILSPIKGAIELYNNNTHDLVGDVKLAGVVMAGIAIGIATAAQITAGVALYEAMKNADNINKLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINTNLVPTIDQISCKQTELALDLALSKYLSDLLFVFGPNLQDPVSNSMTIQAISQAFGGNYETLLRTLGYATEDFDDLLESDSIAGQIVYVDLSSYYIIVRVYFPILTEIQQAYVQELLPVSFNNDNSEWISIVPNFVLIRNTLISNIEVKYCLITKKSVICNQDYATPMTASVRECLTGSTDKCPRELVVSSHVPRFALSGGVLFANCISVTCQCQTTGRAISQSGEQTLLMIDNTTCTTVVLGNIIISLGKYLGSINYNSESIAVGPPVYTDKVDISSQISSMNQSLQQSKDYIKEAQKILDTVNPSMKQIEDKIEEILSKIYHIENEIARIKKLIGEAPGGIEGRKLKETAAAKFERQHMDS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: SER30 TYR31 TYR48 SER49 ASN52 SER55 TRP90 TYR91 SER92 TYR93 D: ASP32 TYR33 TYR34 TYR51 THR53 TYR54 ASP55 SER57 ASN59 PHE99 GLY100 SER101 SER102 TYR103 TRP104 TYR108 B: ASN51 PRO52 LEU53 THR54 LYS55 LYS160 ALA165 GLU166 LYS167 THR168 TYR170 ARG244 LEU246 GLY247 TYR248 ALA249 THR250 GLU251 ASP252 PHE282 ILE284 THR286 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
