Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3910 |
| PDBID: | 7KET |
| Chains: | AB_C |
| Organism: | Homo sapiens, Neisseria meningitidis |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1371/journal.ppat.1009655 |
| Antibody | |
| Antibody: | 7B10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Factor H binding protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7KET_A|Chain B[auth A]|Immunoglobulin gamma, heavy chain Fd fragment|Homo sapiens (9606) QVQLVESGGGLVQPGGSLRLSCVTSGFTFRSYAMTWVRQAPGKGLEWVSSISHSGGSTKYADSVKGRLTISRDDSMDTLYLQMNSLRAEDTAIYYCAKDQISYPAASPLDYWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKLEHHHHHH |
Light Chain: B
Mutation: NULL
| >7KET_B|Chain A[auth B]|Immunoglobulin gamma, kappa light chain|Homo sapiens (9606) AEIVLTQSPGTLSLSPGERATLSCRASQSFSSFSLAWYQQKPGQAPRLLIYAPSNRATGIADRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKLYACEVTHQGLSSPVTKSFNRGECS |
Antigen
Chain: C
Mutation: NULL
| >7KET_C|Chain C|Factor H binding protein|Neisseria meningitidis (487) CSSGGGGVAADIGAGLADALTAPLDHKDKGLQSLTLDQSVRKNEKLKLAAQGAEKTYGNGDSLNTGKLKNDKVSRFDFIRQIEVDGQLITLESGEFQVYKQSHSALTAFQTEQIQDSEHSGKMVAKRQFRIGDIAGEHTSFDKLPEGGRATYRGTAFGSDDAGGKLTYTIDFAAKQGNGKIEHLKSPELNVDLAAADIKPDGKRHAVISGSVLYNQAEKGSYSLGIFGGKAQEVAGSAEVKTVNGIRHIGLAAKQLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: PHE33 SER34 TYR51 ALA52 PRO53 ASN55 ARG56 SER69 GLY94 SER96 A: SER31 TYR32 SER52 HIS53 SER54 GLY56 SER57 THR58 LYS59 GLN100 ILE101 SER102 TYR103 ALA106 C: LYS47 ALA49 ALA50 GLN51 GLY52 GLU54 ASP77 PHE78 ILE79 GLN81 GLU83 GLY86 GLN87 LEU88 THR90 SER93 GLY94 GLU95 GLU112 GLN113 HIS119 SER120 GLY121 LYS122 MET123 ALA125 ARG127 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
