Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 391 |
| PDBID: | 2XTJ |
| Chains: | DB_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | 10.1194/jlr.M011445 |
| Antibody | |
| Antibody: | 1D05 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) |
| Antigen mutation: | No |
| Durg Target: | Q8NBP7 |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >2XTJ_D|Chain D|FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05|HOMO SAPIENS (9606) QVQLVQSGAEVKKPGSSVKVSCKASGGTFNSHAISWVRQAPGQGLEWMGGINPILGIANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARHYEIQIGRYGMNVYYLMYRFASWGQGTLVTVSS |
Light Chain: B
Mutation: NULL
| >2XTJ_B|Chain B|FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05|HOMO SAPIENS (9606) DIQMTQSPSSLSASVGDRVTITCRASQGIRSALNWYQQKPGKAPKLLIYNGSTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQFDGDPTFGQGTKVEIKR |
Antigen
Chain: A
Mutation: NULL
| >2XTJ_A|Chain A|PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9|HOMO SAPIENS (9606) SIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLILFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAAGTAAASHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ASP1 GLN27 ARG30 PHE91 ASP92 GLY93 ASP94 D: LEU55 GLY56 ILE57 ALA58 ASN59 TYR60 GLN62 GLN65 ILE104 ARG106 TYR107 MET109 ASN110 VAL111 TYR112 TYR113 LEU114 TYR116 A: PRO155 ASP192 ARG194 GLU197 ALA220 SER221 ARG237 ASP238 ALA239 ILE369 SER372 ASP374 CYS375 SER376 THR377 CYS378 PHE379 VAL380 SER381 GLN382 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
