Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 388 |
| PDBID: | 2XQY |
| Chains: | JK_E |
| Organism: | Suid alphaherpesvirus 1, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.05 |
| Reference: | 10.1073/pnas.1011507107 |
| Antibody | |
| Antibody: | A13-D6.3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Core Fragment of Glycoprotein H from Pseudorabies Virus |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: J
Mutation: NULL
| >2XQY_J|Chain C[auth G], D[auth J]|A13-D6.3 MONOCLONAL ANTIBODY|MUS MUSCULUS (10090) RSKLLDQVQLQQPGAELVKPGASVKMSCKASGYSFTSYWMNWVKQRPGRGLEWIGRIDPSDNETHYNQDFKDKVTLTVDKSSSTVYIQLSSLTSEDSAVYYCGRLGYVYGFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRASDDDDKAGWSHPQFEKGGGSGGGSGGGSWSHPQFEK |
Light Chain: K
Mutation: NULL
| >2XQY_K|Chain E[auth K], F[auth L]|A13-D6.3 MONOCLONAL ANTIBODY|MUS MUSCULUS (10090) RSDIVLTQSPASLALSLGQRATISCRASKSVSTSGYSYMYWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQHSRELPWTFGGGTKLEINRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: E
Mutation: NULL
| >2XQY_E|Chain A, B[auth E]|ENVELOPE GLYCOPROTEIN H|SUID HERPESVIRUS (10345) RSQRPRERPRLSGPPSGAELVAFDAPGVRRTYTTAAVWPAEVAVLADAEARCPAAVFNVTLGEAFLGLRVALRSFLPLEVIISAERMRMIAPPALGSDLEPPGPPAGRFHVYTLGFLSDGAMHQTMRDVAAYVHESDDYLAQLSAAHAAALAAVVQPGPYYFYRAAVRLGVAAFVFSEAARRDRRASAPALLRVESDARLLSRLLMRAAGCPAGFAGLFDGRAERVPVAPADQLRAAWTFGEDPAPRLDLARATVAEAYRRSVRGKPFDQQALFFAVALLLRAGGPGDARETLLRTTAMCTAERAAAAAELTRAALSPTAAWNEPFSLLDVLSPCAVSLRRDLGGDATLANLGAAARLALAPAGAPGAAAATDEGAEEEEEDPVARAAPEIPAEALLALPLRGGASFVFTRRRPDCGPAYTLGGVDIANPLVLAIVSNDSAACDYTDRMPESQHLPATDNPSVCVYCDCVFVRYSSAGTILETVLIESKDMEEQLMAGANSTIPSFNPTLHGGDVKALMLFPNGTVVDLLSFTSTFEDDDDKAGWSHPQFEKGGGSGGGSGGGSWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| J: GLN1 VAL2 GLY26 TYR27 SER28 THR30 SER31 TYR32 TRP33 SER53 ASP54 GLU56 ARG94 TYR97 VAL98 TYR99 ASP101 TYR102 K: TYR30 TYR32 TYR49 LEU50 SER52 ASN53 LEU54 GLU55 SER56 GLY57 E: PRO293 ALA294 ARG297 PRO331 VAL332 ALA333 PRO334 ALA335 GLN337 PRO350 ARG351 ASP353 LEU354 ARG356 ALA357 THR358 ALA360 GLU361 ALA362 ARG364 ARG365 ARG368 LYS370 PRO371 PHE372 ASP373 ALA376 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
