Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 386 |
| PDBID: | 2XQB |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1016/j.jmb.2010.12.017 |
| Antibody | |
| Antibody: | DISC0280 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin 15 |
| Antigen mutation: | No |
| Durg Target: | P40933 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >2XQB_H|Chain B[auth H]|ANTI-IL-15 ANTIBODY|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYSFSSFGISWVRQAPGQGLEWLGWISAFNGYTKYAQKFQDRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDPAAWPLQQSLAWFDPWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHQYVL |
Light Chain: L
Mutation: NULL
| >2XQB_L|Chain C[auth L]|ANTI-IL-15 ANTIBODY|Homo sapiens (9606) TQPPSASGTPGQRVTISCSGSTSNLKRNYVYWYQQLPGTAPKLLIYRDRRRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAWYDRELSEWVFGGGTKLTVLQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >2XQB_A|Chain A|INTERLEUKIN 15|Homo sapiens (9606) NWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR27 SER28 SER31 PHE32 PHE53 ARG94 PRO96 ALA98 TRP99 ASP101 L: ASN31 TYR32 LEU46 TYR49 ARG50 ARG53 ARG54 PRO55 SER56 A: ASP22 ALA23 THR24 LEU25 TYR26 THR38 LYS41 LEU44 LEU45 GLU46 GLN48 VAL49 LEU52 GLU53 GLY55 HIS60 VAL63 GLU64 ILE67 ILE68 ASN71 ASN72 LEU74 SER75 CYS88 GLU89 GLU93 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
