Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3828 |
| PDBID: | 7JX3 |
| Chains: | CD_R |
| Organism: | Homo sapiens, Severe acute respiratory syndrome coronavirus 2 |
| Method: | XRD |
| Resolution (Å): | 2.65 |
| Reference: | 10.1016/j.cell.2020.09.037 |
| Antibody | |
| Antibody: | S2H14 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2; P0DTC2; P0DTC2; |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >7JX3_C|Chain D[auth C]|Heavy chain of Fab domain of monoclonal antibody S2H14|Homo sapiens (9606) EVQLVESGGGLVKPGGSLRLSCAASGFTFSNAWMSWVRQAPGKGLEWVGRIKSKTDGGTTDYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTGSETYYYDSSGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: D
Mutation: NULL
| >7JX3_D|Chain C[auth D]|Light chain of Fab domain of monoclonal antibody S2H14|Homo sapiens (9606) NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSNQVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: R
Mutation: NULL
| >7JX3_R|Chain G[auth R]|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) RFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKST |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: SER25 SER26 GLY27 SER28 ALA30 SER31 ASN32 TYR33 GLU51 SER69 SER70 ASN72 SER96 C: ASN31 TRP33 LYS52 SER53 LYS54 THR55 ASP56 GLY57 THR59 GLU103 THR104 TYR105 TYR106 TYR107 ASP108 SER109 R: ARG403 LYS417 VAL445 GLY446 TYR449 TYR453 LEU455 PHE456 ALA475 GLU484 GLY485 PHE486 ASN487 TYR489 GLN493 SER494 TYR495 GLY496 GLN498 PRO499 THR500 ASN501 GLY502 TYR505 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
