Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3800 |
| PDBID: | 7JTG |
| Chains: | AB_E |
| Organism: | Macaca mulatta, Recombinant Hepatitis C virus HK6a/JFH-1 |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | RM11-43 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C Virus Envelope Glycoprotein E2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7JTG_A|Chain A|RM11-43 Fab heavy chain|Macaca mulatta (9544) QVQLVQSGAEVKKPGASVKLSCKASGFTFRIYAISWVRQAPGQGLEWMGEIIPLGGITNYAQKFQGRVTITADTSTSTAYMELSSLRSEDTAVYYCARGETKMITVLAGTTGGGLDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGS |
Light Chain: B
Mutation: NULL
| >7JTG_B|Chain B|RM11-43 Fab light chain|Macaca mulatta (9544) DIQMTQSPSSLSASVGDKVTITCHASQGISSWLAWYQQKPGKAPKPLIYAASSLQSGVPSRFSGGGSGADYTLTISSLQPEDFATYYCQQYDDLPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >7JTG_E|Chain C[auth E]|Envelope glycoprotein E2|Recombinant Hepatitis C virus HK6a/JFH-1 (595609) QLINTNGSWHINRTALNCNDSLQTGFITSLFYAKNVDSSGCPERMAACGSSGCWHYAPRPCDVVSARTVCGPVYCFTPSPVVVGTTDKLGIPTYNWGENETDVFMLESLRPPTGGWFGCTWMNSTGFTKTCGAPPGGPTDGGSGPWITPRCLVDYPYRLWHYPCTVNFTLHKVRMFVGGIEHRFDAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR28 ARG30 ILE31 GLU50 LEU53 GLY54 ILE56 THR97 LYS98 MET99 B: ASP92 ASP93 LEU94 ARG96 E: HIS421 ILE422 ASN423 THR425 LEU427 CYS429 ILE438 THR439 SER440 LEU441 PHE442 TYR443 ALA444 PRO505 TYR507 VAL515 TRP529 GLU531 PRO612 TYR613 TRP616 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
