Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3798 |
| PDBID: | 7JTF |
| Chains: | AB_E |
| Organism: | Macaca mulatta, Recombinant Hepatitis C virus HK6a/JFH-1 |
| Method: | XRD |
| Resolution (Å): | 3.35 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | RM2-01 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C Virus Envelope Glycoprotein E2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7JTF_A|Chain A, D[auth C]|RM2-01 Fab heavy chain|Macaca mulatta (9544) QVQLVQSGAEVKKPGASVKLSCKASGFTFRIYAISWVRQAPGQGLEWMGEIVPLGGITNYAQNFQGRAAITADTSINTAYMELSSLRSDDTAVYYCARVRTALVGPREGIFDFWGQGVLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGS |
Light Chain: B
Mutation: NULL
| >7JTF_B|Chain B, E[auth D]|RM2-01 Fab light chain|Macaca mulatta (9544) DIQMTQSPSSLSASVGDRVSITCRASQTISTYLAWYQQKPGKVPKLLIYTASTLETGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQHDSHPYSFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >7JTF_E|Chain C[auth E], F|Envelope glycoprotein E2|Recombinant Hepatitis C virus HK6a/JFH-1 (595609) QLINTNGSWHINRTALNCNDSLQTGFITSLFYAKNVDSSGCPERMAACGSSGCWHYAPRPCDVVSARTVCGPVYCFTPSPVVVGTTDKLGIPTYNWGENETDVFMLESLRPPTGGWFGCTWMNSTGFTKTCGAPPGGPTDGGSGPWITPRCLVDYPYRLWHYPCTVNFTLHKVRMFVGGIEHRFDAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR28 ARG30 ILE31 ALA33 ILE51 PRO52 GLY54 ILE56 ASN58 ARG96 THR97 ALA98 LEU99 B: ASP92 SER93 HIS94 TYR96 E: ILE422 THR425 LEU427 GLY436 ILE438 THR439 LEU441 PHE442 TYR443 ALA444 PRO505 TRP529 GLU531 TYR613 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
