Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3796 |
| PDBID: | 7JR7 |
| Chains: | CD_B |
| Organism: | Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.30 |
| Reference: | 10.1038/s42003-021-02039-8 |
| Antibody | |
| Antibody: | 11F4 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | ATP-binding cassette sub-family G member 5 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >7JR7_C|Chain C|Fab 11F4 heavy chain|Homo sapiens (9606) DVQLQESGPGLVKPSQSLSLTCTITGYSITSDYAWNWIRQFPGNKLEWMGYISYSGTTYYNPSLKSRFSITRDTSRNQFFLQFNSVTTEDTGTYFCARMITTVYYFDYWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD |
Light Chain: D
Mutation: NULL
| >7JR7_D|Chain D|Fab 11F4 light chain|Homo sapiens (9606) QIVLTQSPTIMSASLGERVTMTCTASSSASSSYLHWYQQKPGSSPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISNMEAEDAATYYCHQHHRSPPTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTATLTKDEYERHNSYTCEATHKTSTSPIVKSFNRA |
Antigen
Chain: B
Mutation: NULL
| >7JR7_B|Chain B|ATP-binding cassette sub-family G member 8|Homo sapiens (9606) MAGKAAEERGLPKGATPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYVSLRFIKQKPSQDW |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: THR30 SER31 ASP32 ALA34 TYR51 SER53 TYR54 SER55 THR57 THR58 TYR59 MET99 THR101 THR102 TYR104 D: SER27 SER28 ALA29 SER30 SER31 TYR33 SER68 GLY69 THR70 HIS92 HIS93 ARG94 SER95 B: VAL301 GLN302 THR305 ALA306 ILE307 GLY308 TYR309 PRO310 CYS311 PRO312 ARG313 TYR314 PHE320 LEU324 GLU333 GLN334 LEU336 ALA337 THR338 GLU340 LYS341 SER344 LEU348 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
