Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3795 |
| PDBID: | 7JOO |
| Chains: | HL_C |
| Organism: | Lama glama, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | 10.1038/s41467-020-18828-4 |
| Antibody | |
| Antibody: | STIM003 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Alomfilimab(Phase-II) |
| Antigen | |
| Antigen: | Inducible T cell costimulator |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7JOO_H|Chain B[auth H]|STIM003 Fab Heavy chain|Homo sapiens (9606) EVQLVESGGGVVRPGGSLRLSCVASGVTFDDYGMSWVRQAPGKGLEWVSGINWNGGDTDYSDSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCARDFYGSGSYYHVPFDYWGQGILVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >7JOO_L|Chain C[auth L]|STIM003 Fab Light chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQSVSRSYLAWYQQKRGQAPRLLIYGASSRATGIPDRFSGDGSGTDFTLSISRLEPEDFAVYYCHQYDMSPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >7JOO_C|Chain D[auth C]|Inducible T-cell costimulator|Homo sapiens (9606) TGEIQGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLAAQGTENLYFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP30 ASP31 TRP52 ASN53 ASP56 ASP58 TYR97 GLY98 SER99 L: SER31 TYR32 TYR49 GLY50 SER53 SER94 C: GLN49 GLN50 LYS52 THR66 THR68 LYS69 GLY70 SER71 GLY72 ASN73 THR74 SER76 ILE77 LYS78 LEU80 PHE114 ASP115 PRO116 PRO117 PRO118 PHE119 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
