Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3790 |
| PDBID: | 7JLN |
| Chains: | AB_H |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.57 |
| Reference: | 10.1016/j.celrep.2021.109084 |
| Antibody | |
| Antibody: | anti-idiotype iv9 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | glVRC01 Fab heavy chain |
| Antigen mutation: | No |
| Durg Target: | P01857; P23083; Q6PYX1; P01859; P01861; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7JLN_A|Chain A|iv9 Heavy Chain|Mus musculus (10090) QVQLQQPGAELVRPGTSIMLSCKTSGYTFTSYWINWVKQRPGQGLEWIGNIWPSDSYTNYNQRFKGKATLTVDKSSNTAFMQLSSPTSEDSAVYYCTRDFGASYVGFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: B
Mutation: NULL
| >7JLN_B|Chain B|iv9 Light Chain|Mus musculus (10090) DIVMTQSPSSLSVSAGERVTLSCKSSQSLLNSGNQKNYLAWYQQKPGQPPKLLIYGASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCQNDESYPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: H
Mutation: NULL
| >7JLN_H|Chain C[auth H]|glVRC01 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGKNSDYNWDFQHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR30 SER31 TRP33 ASN50 SER53 ASP54 TYR56 ASN58 ASP95 ALA98 SER99 B: GLY27 ASN28 LYS30 TYR32 ASP91 GLU92 SER93 TYR94 TYR96 H: GLU10 LYS12 LYS13 PRO14 GLY15 ALA16 SER17 VAL18 LYS19 GLN61 LYS62 GLN64 GLY65 ARG66 VAL67 THR68 GLU81 LEU82 ARG83 SER84 ASP85 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
