Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3788 |
| PDBID: | 7JLK |
| Chains: | HL_A |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.99 |
| Reference: | 10.1016/j.celrep.2021.109084 |
| Antibody | |
| Antibody: | anti-idiotype iv1 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | glVRC01 Fab heavy chain |
| Antigen mutation: | No |
| Durg Target: | P01857; P23083; Q6PYX1; P01859; P01861; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7JLK_H|Chain A[auth H]|iv1 Heavy Chain|Mus musculus (10090) QIQLVQSGPELKKPGETVKISCKASGYTFTNYEINWVQQAPGKGLKLMGWINTYTGEPTSADDFKGRFAFSLETSASTAYLQINNLKNEDAATYFCARGDYYGSSSAWLPYWGQGTLVTVSAGSGSGHHHHHH |
Light Chain: L
Mutation: NULL
| >7JLK_L|Chain D[auth L]|iv1 Light Chain|Mus musculus (10090) DIVMTQSQKFMSTSVGDRVSITCKASQNVRTAVAWYQQKPGQSPKALIFLASNRHTGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCLQHWNYPLTFGGGTKLEIKGGGGSGGGGSGGGGS |
Antigen
Chain: A
Mutation: NULL
| >7JLK_A|Chain B[auth A]|glVRC01 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGKNSDYNWDFQHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ILE2 TYR32 TYR97 TYR98 GLY99 TYR102 L: ARG30 THR31 PHE49 LEU50 SER52 ASN53 ARG54 THR56 TRP92 A: TYR33 TRP47 TRP50 ASN53 SER54 GLY56 THR57 ASN58 TYR59 ALA60 GLN61 GLN64 ASP99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
