Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3787 |
| PDBID: | 7JKT |
| Chains: | HL_G |
| Organism: | Human immunodeficiency virus 1, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.75 |
| Reference: | 10.1016/j.immuni.2020.12.014 |
| Antibody | |
| Antibody: | 2413a Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 strain d45-01dG5 gp120 |
| Antigen mutation: | No |
| Durg Target: | P35961 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7JKT_H|Chain B[auth H]|Heavy chain of antibody 2413a|Mus musculus (10090) QVQLVQSGPEVRAPGASVTVSCKTSGYSFTDFFIHWVRQAPGQGLEWMGWLNPIFGAVNYAHKYQGRITLTRDTSMKTAYMQLTNLRSDDTAVFYCVRKRVYDEYDWDWAYWGQGTLVTVSAASTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCDKGLEVLFQ |
Light Chain: L
Mutation: NULL
| >7JKT_L|Chain C[auth L]|Light chain of antibody 2413a|Mus musculus (10090) EIVLTQSPGILSLSPGERATLSCRTSQDVGSNSLAWYQEKPGQAPRLLVYGASNRATGVPDRFSGGGSGTDFTLTISRLEPEDFAVYYCQQYEYFGRGTKVQVDIKRTDAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: G
Mutation: NULL
| >7JKT_G|Chain A[auth G]|HIV-1 gp120 core from strain d45-01dG5|Human immunodeficiency virus 1 (11676) VWKEATATLFCASDAKAYETEVHNVWATHACVPTDPNPQEVVLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTGGSVITQACPKISFEPIPIHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEIVIRSENITDNAKIIIVQLNETVEINCTRPNNGGSGSGGDIRQAHCNISKAKWENTLKQIARKLREHFKNETIAFNQSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWTWNDTEVVNNTEKNINITLPCRIKQIINMWQEVGKAMYAPPIKGQIRCSSNITGLLLTRDGGSSTNGTTETFRPGGGDMRDNWRSELYKYKVVKIEGSLEVLFQGPGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR30 PHE33 TRP47 TRP50 PRO52 ILE53 PHE54 GLY55 ALA56 VAL57 ASN58 TYR59 ALA60 HIS61 LYS62 GLN64 ARG71 THR73 TYR98 ASP99 L: GLU1 ILE2 GLN27 TYR96 GLU97 TYR98 G: LYS97 THR257 ASN276 THR278 ASP279 ASN280 ALA281 LYS282 GLU357 SER365 GLY366 GLY367 ASP368 GLU370 ILE371 ASN425 MET426 TRP427 VAL430 THR455 ARG456 ASP457 GLY458 GLY459 SER460 SER461 THR462 GLY464 THR466 GLU467 THR468 ARG470 GLY473 GLY474 ASP475 ARG477 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
