Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3785 |
| PDBID: | 7JIX |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Solomon Islands/3/2006 (Egg passage)(H1N1)), Influenza A virus (A/Mexico/UASLP-006/2008(H1N1)), Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.90 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 7JIX Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7JIX_H|Chain D[auth H]|Fab heavy chain|Mus musculus (10090) ASEVQLQESGPELVKPGASVKISCKASGYAFSRSWMNWVKQRPGKGLEWIGRIYPGDGDTNYNGKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYFCARGSNSFAYWGQGTLVTVSGAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGHHHHHH |
Light Chain: L
Mutation: NULL
| >7JIX_L|Chain C[auth L]|Fab light chain|Mus musculus (10090) ASDIVLTQSPASLAVSLGQRATISCKASQSVDFDGDSYMNWYQQKPGQPPKLLIYTTSNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSSEDPYTFGGGTKLEIKRADGAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >7JIX_A|Chain A|Hemagglutinin HA1 chain|Influenza A virus (A/Solomon Islands/3/2006 (Egg passage)(H1N1)) (464622) ADPGYLLEDTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHTENAYVSVVSSHYSRKFTPEIAKRPKVRDREGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGFGSGIINSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ASP1 GLN27 SER28 ASP30 PHE31 ASP32 GLY33 ASP34 TYR36 THR54 SER95 SER96 GLU97 ASP98 PRO99 TYR100 H: ALA28 ARG31 SER32 TRP33 TRP47 ARG50 TYR52 GLY54 ASP55 ASP57 THR58 ASN59 GLY62 ARG98 GLY99 SER100 ASN101 A: GLU72 LEU73 ILE75 TYR95 ARG117 LYS123 GLU124 THR131 THR132 THR133 GLY134 VAL135 SER136 ALA137 HIS141 ASN142 GLY143 GLU144 SER145 LYS149 TRP153 THR155 GLY156 LYS157 ASN158 GLY159 HIS183 PRO186 ASP190 ALA193 LEU194 HIS196 ASP225 ARG226 GLU227 GLY228 ARG255 TYR256 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
