Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3763 |
| PDBID: | 7FEJ |
| Chains: | HL_2 |
| Organism: | Foot-and-mouth disease virus, Bos taurus |
| Method: | EM |
| Resolution (Å): | 3.91 |
| Reference: | 10.1128/JVI.01308-21 |
| Antibody | |
| Antibody: | R55 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Foot-and-mouth disease virus (FMDV) A/AF/72 VP2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7FEJ_H|Chain E[auth H]|IG HEAVY CHAIN VARIABLE REGION|Bos taurus (9913) QVQLRESGPSLVKPSQTLSLTCTVSGFSLSDYAVGWVRQAPGKALEFLGSISTGGNTGYNPALKSRLSITKDNSKNQVSLSLSSVTTEDTATYYCTKSIHSYSVFEYTYMQYVDAWGQGLLVPVSS |
Light Chain: L
Mutation: NULL
| >7FEJ_L|Chain F[auth L]|IG LAMDA CHAIN VARIABLE REGION|Bos taurus (9913) WAQAVLTQPSSVSGSLGQRVSITCSGSSNNIGRYDVGWYQQIPGSGLRTIIYASKNRPSGVPDRFSGSRSGNTATLTISSLQAEDEADYFCATGDYSSSTSVFGSGTTLTVLGDYKDDDDKGG |
Antigen
Chain: 2
Mutation: NULL
| >7FEJ_2|Chain B[auth 2]|A/AF/72 VP2|Foot-and-mouth disease virus (12110) DKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYSTGEDHVSGPNTSGLETRVTQAERFFKKHLFDWTTDKAFGHLEKLELPTDHKGVYGHLVDSFAYMRNGWDVEVSAVGNQFNGGCLLVAMVPEYKDFTLREKYQLTLFPHQFISPRTNMTAHITVPYLGVNRYDQYKKHKPWTLVVMVLSPLTVNNSGAGQIKVYANIAPTYVHVAGELPSKE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP31 TYR32 ILE99 HIS100 SER101 TYR102 VAL104 PHE105 THR108 GLN111 TYR112 L: GLY32 ARG33 TYR34 ASP35 ALA53 SER54 LYS55 ASN56 ARG69 SER70 2: HIS65 LEU66 PHE67 ASP68 THR70 THR71 ASP72 LYS73 ALA74 PHE75 GLY76 HIS77 LEU78 GLU79 PHE132 THR133 LEU134 ARG135 PRO186 VAL189 GLY195 GLN196 LYS198 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
