Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3759 |
| PDBID: | 7FCP |
| Chains: | BD_A |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | 10.1172/JCI154987 |
| Antibody | |
| Antibody: | P5-22 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2; P0DTC2; |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >7FCP_B|Chain D[auth B]|P5-22 antibody Fab fragment heavy chain|Homo sapiens (9606) EVQLVESGGGLVKPGGSLRLSCAASGFTFRDYDIIWIRQAPGKGLEWVSYISRSGSTIYYSDSVRGRFTISRDNAKNSVYLQMNSLRAEDTAVYYCARDFGFEGPRMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: D
Mutation: NULL
| >7FCP_D|Chain E[auth D]|P5-22 antibody Fab fragment light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCQASQDIKNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQFDNLPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7FCP_A|Chain A|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) VDQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSSRGS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: PHE27 THR28 ARG30 ASP31 ASP33 ILE35 TYR50 SER52 ARG53 SER54 THR57 TYR59 ASN74 ALA75 ASP99 PHE100 GLY101 PHE102 GLU103 ARG106 D: LYS30 TYR32 PHE91 ASP92 ASN93 LEU94 ILE96 A: ARG403 LYS417 TYR421 GLY446 TYR449 TYR453 LEU455 PHE456 TYR473 ALA475 GLY476 SER477 THR478 GLU484 GLY485 PHE486 ASN487 TYR489 PHE490 PRO491 LEU492 GLN493 SER494 TYR495 GLY496 GLN498 TYR505 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
