Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3748 |
| PDBID: | 7FBJ |
| Chains: | B_A |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Chiloscyllium plagiosum |
| Method: | XRD |
| Resolution (Å): | 2.85 |
| Reference: | 10.1002/smtd.202200387 |
| Antibody | |
| Antibody: | 17F6 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >7FBJ_B|Chain B, D, F, H, J, L, N, P|New antigen receptor variable domain|Chiloscyllium plagiosum (36176) MAMAERVEQTPTTTTKETGESLTINCVLRDSSCALDSTYWYFTKKGATKKESLSNGGRYAETVNKASKSFSLRISDLRVEDSGTYHCRAYSLSAGMCAWMGYIEGGGTIVTVNSSGSSGLEHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >7FBJ_A|Chain A, C, E, G, I, K, M, O|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) DAAQPAITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPAAARGGPEQKLISEEDLNSAVDHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ALA0 GLU1 TYR37 THR44 LYS46 ARG84 TYR86 LEU88 ALA94 TRP95 MET96 GLY97 TYR98 ILE99 GLU100 GLY101 GLY102 A: TYR369 ASN370 ALA372 SER373 PHE374 SER375 THR376 PHE377 LYS378 CYS379 TYR380 GLY381 VAL382 SER383 PRO384 THR385 ARG408 PRO412 ASN440 VAL503 TYR508 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
