Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3747 |
| PDBID: | 7FAU |
| Chains: | D_C |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Camelidae |
| Method: | XRD |
| Resolution (Å): | 2.08 |
| Reference: | 10.1016/j.str.2022.02.011 |
| Antibody | |
| Antibody: | 1B11 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >7FAU_D|Chain B, D|NB_1B11|Camelidae (9835) QVQLQESGGGSVQAGGSLRLSCAASGYTVSVGCMAWFRQAPGKEREGVAGIDASGITKYSDSVKGRFTISKDNAKNALDLQMNGLKPEDTAMYHCAAGLVRGSCTDVLDHPSYLGVWGQGTQVTVSS |
Antigen
Chain: C
Mutation: NULL
| >7FAU_C|Chain A, C|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) MFVFLVLLPLVSSQCTNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATSRAAADYKDDDDK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: VAL2 GLN3 GLY26 TYR27 VAL31 GLY32 CYS33 GLN39 ARG45 ALA53 HIS94 GLY98 LEU99 VAL100 ARG101 GLY102 SER103 CYS104 SER112 LEU114 GLY115 VAL116 TRP117 GLY118 GLN119 C: TYR351 GLY446 TYR449 ASN450 LEU452 LEU455 PHE456 THR470 ILE472 GLY482 VAL483 GLU484 GLY485 PHE486 TYR489 PHE490 LEU492 GLN493 SER494 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
