Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3633 |
| PDBID: | 7E3O |
| Chains: | HL_R |
| Organism: | Homo sapiens, Severe acute respiratory syndrome coronavirus 2 |
| Method: | XRD |
| Resolution (Å): | 2.51 |
| Reference: | 10.1128/Spectrum.01352-21 |
| Antibody | |
| Antibody: | nCoV617 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7E3O_H|Chain B[auth H]|nCoV617 Heigh Chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVALISYDGSNKYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGLGLRFLEWPISSYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >7E3O_L|Chain A[auth L]|nCoV617 Light Chain|Homo sapiens (9606) QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNWYQQLPGTAPKLLIFSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLKGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: R
Mutation: NULL
| >7E3O_R|Chain C[auth R]|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) PFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER32 ASN33 THR34 PHE51 SER52 ASN53 GLN55 ARG56 PRO57 SER58 TRP93 ASP95 LEU97 H: GLN1 VAL2 SER25 GLY26 PHE27 THR28 TYR32 LEU50 LYS58 ARG97 LEU99 GLY100 LEU101 ARG102 PHE103 LEU104 GLU105 TRP106 TYR111 R: ARG346 TYR351 ALA352 ARG403 LYS444 VAL445 GLY446 GLY447 TYR449 ASN450 LEU452 LEU455 PHE456 ILE468 THR470 GLU471 ILE472 GLY482 VAL483 GLU484 GLY485 PHE486 CYS488 TYR489 PHE490 LEU492 GLN493 SER494 TYR495 GLY496 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
