Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3625 |
| PDBID: | 7DX4 |
| Chains: | HL_E |
| Organism: | Homo sapiens, Severe acute respiratory syndrome coronavirus 2 |
| Method: | EM |
| Resolution (Å): | 3.60 |
| Reference: | 10.1093/nsr/nwab053 |
| Antibody | |
| Antibody: | FC08 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7DX4_H|Chain C[auth H]|Heavy chain of FC08 Fab|Homo sapiens (9606) QLLQQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIIGIANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARERGYSGYGAAYYFDYWGQGTLVTVSSA |
Light Chain: L
Mutation: NULL
| >7DX4_L|Chain D[auth L]|Light chain of FC08 Fab|Homo sapiens (9606) SVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGSVFGGGTKLTVLGQ |
Antigen
Chain: E
Mutation: NULL
| >7DX4_E|Chain B[auth E]|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR29 SER31 SER32 TYR33 ALA34 ILE53 ILE55 ILE56 ILE58 ASN60 GLU100 ARG101 GLY102 TYR103 SER104 GLY105 TYR106 GLY107 ALA108 ALA109 L: SER26 SER27 GLY30 ALA31 GLY32 TYR33 GLY70 THR71 TYR93 SER95 SER96 SER98 E: ARG346 ALA348 TYR351 ALA352 TRP353 ASN354 ARG355 LYS356 ARG357 SER359 TYR396 TYR449 ASN450 LEU452 ARG457 LYS462 PRO463 PHE464 GLU465 ARG466 ASP467 ILE468 SER469 THR470 GLU471 ILE472 ASN481 GLY482 VAL483 GLU484 PHE490 LEU492 SER494 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
