Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3624 |
| PDBID: | 7DUO |
| Chains: | HL_B |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.81 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | Daratumumab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Daratumumab(Approved) |
| Antigen | |
| Antigen: | CD38 |
| Antigen mutation: | No |
| Durg Target: | P28907 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7DUO_H|Chain A[auth H]|Fab heavy chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAVSGFTFNSFAMSWVRQAPGKGLEWVSAISGSGGGTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCAKDKILWFGEPVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK |
Light Chain: L
Mutation: NULL
| >7DUO_L|Chain C[auth L]|Fab light chain|Homo sapiens (9606) EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: B
Mutation: NULL
| >7DUO_B|Chain B|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1|Homo sapiens (9606) KRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR28 ASN30 SER31 SER52 GLY53 SER54 GLY56 GLY57 THR58 TYR59 LYS65 LEU102 TRP103 PHE104 GLY105 GLU106 L: TYR32 ARG91 SER92 ASN93 TRP94 B: ASN76 LYS77 PHE91 GLN95 ASP97 MET98 ASP158 VAL159 HIS161 GLN192 THR193 GLU195 TRP197 ASP208 CYS210 GLN228 PHE229 SER230 CYS231 LYS232 ASN233 TYR235 PHE240 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
