Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3623 |
| PDBID: | 7DQ7 |
| Chains: | HL_B |
| Organism: | Coxsackievirus B1, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.20 |
| Reference: | 10.1016/j.chom.2021.01.001 |
| Antibody | |
| Antibody: | 5F5 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Coxsackievirus B1 VP2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7DQ7_H|Chain F[auth H]|5F5 VH|Mus musculus (10090) EIQLQQSGPELVKPGASVKVSCKASGYSFTDYNIYWVKQSHGKSLEWIGYVDPYNGNTNYNQKFKGKATLTVDKSSSTAFMHLNSLTSEVSTVYYCARGGGYYGGGYYGMDYWGQGTSVTVSS |
Light Chain: L
Mutation: NULL
| >7DQ7_L|Chain E[auth L]|5F5 VL|Mus musculus (10090) QIVLSQSPAILSASPGEKVTMTCRASSSVSYLHWYQQKPGSSPKPWISATSNLASGVPARFSGSGSGTSYSLTISRVEAEDAATYYCQQWSSNPLSFGGGTKLELK |
Antigen
Chain: B
Mutation: NULL
| >7DQ7_B|Chain B|VP2|Coxsackievirus B1 (12071) SPSAEECGYSDRVRSITLGNSTITTQECANVVVGYGVWPEYLKDNEATAEDQPTQPDVATCRFYTLESVQWMKNSAGWWWKLPDALSQMGLFGQNMQYHYLGRTGYTIHVQCNASKFHQGCLLVVCVPEAEMGCSNLNNTPEFSELSGGDSARMFTDTQVGESNAKKVQTAVWNAGMGVGVGNLTIFPHQWINLRTNNSATLVMPYINSVPMDNMFRHNNLTLMIIPFVPLNYSEGSSPYVPITVTIAPMCAEYNGLRLASNQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER30 TYR31 THR50 SER51 ASN52 LEU53 ALA59 PHE61 SER62 SER64 GLY65 SER66 H: SER28 THR30 ASP31 TYR32 ASP52 TYR54 GLY100 GLY101 TYR104 TYR105 B: GLU67 SER68 VAL69 GLN70 MET72 LYS73 ASN74 SER75 GLU142 SER144 GLU145 SER151 ARG153 MET154 PHE155 THR156 SER163 ASN164 ALA165 LYS166 LYS167 TYR233 GLU235 GLY236 SER237 SER238 PRO239 TYR240 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
