Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 362 |
| PDBID: | 2VXQ |
| Chains: | HL_A |
| Organism: | Phleum pratense, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.4049/jimmunol.0803018 |
| Antibody | |
| Antibody: | 2VXQ Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | pollen allergen Phl p 2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >2VXQ_H|Chain B[auth H]|FAB|HOMO SAPIENS (9606) VQLLESGPGLVKPAQTLSLSCAVSGGSIRSGGYYWSWIRQHPGKGLEWIGYIYHSGNTYYNPSLKSRIAMSVDTSENKFSLRLNSVTAADTAVYYCARLDGYTLDIWGQGTLVTVSSSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Light Chain: L
Mutation: NULL
| >2VXQ_L|Chain C[auth L]|FAB|HOMO SAPIENS (9606) EIEMTQSPSSLSASVGDRVTISCRASQRINTYLNWYQHKPGKAPKLLIYAASSLQSGVPSRFSGSGYGTDFTLTISSLQPEDFASYYCQESLSASYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >2VXQ_A|Chain A|POLLEN ALLERGEN PHL P 2|PHLEUM PRATENSE (15957) VPKVTFTVEKGSNEKHLAVLVKYEGDTMAEVELREHGSDEWVAMTKGEGGVWTFDSEEPLQGPFNFRFLTEKGMKNVFDDVVPEKYTIGATYAPEE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER30 GLY31 GLY32 TYR33 TYR34 TYR53 HIS54 SER55 ASN57 TYR59 ASP100 GLY101 TYR102 THR103 L: GLU1 ILE2 GLN27 TYR32 TYR49 ALA50 GLN55 SER91 LEU92 SER93 ALA94 SER95 TYR96 A: GLU30 GLU32 ARG34 HIS36 ASP39 GLU40 TRP41 ALA43 ASN65 ARG67 PHE68 LEU69 GLY73 MET74 LYS75 ASN76 VAL77 PHE78 ASP79 ASP80 PRO94 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
