Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3614 |
| PDBID: | 7DM1 |
| Chains: | DC_A |
| Organism: | Mycobacterium tuberculosis H37Rv, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1038/s41467-021-20930-0 |
| Antibody | |
| Antibody: | p4-36 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Phosphate-binding protein PstS 1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >7DM1_D|Chain D, F|heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGRSLRLSCTDSGFTFSEYALSWVRQAPGKGLEWVGFIRSKAYGGTTEYAASVKGRFTISRDDSKSVAYLQMNSLKTEDTAVYFCTGPRPYYDSSGYYPYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: C
Mutation: NULL
| >7DM1_C|Chain C, E|light chain|Homo sapiens (9606) SWAQSALTQPRSVSGSPGQSVTISCTGSRSDVGGYDYVSWYQQHPGRVPKLMIYDVTKRPSGVPDRFSGSRSGNTASLTISGLQADDEADYYCSSFAGSSTYVVFGGGTTLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >7DM1_A|Chain A, B|Phosphate-binding protein PstS 1|Mycobacterium tuberculosis H37Rv (83332) MGSKPPSGSPETGAGAGTVATTPASSPVTLAETGSTLLYPLFNLWGPAFHERYPNVTITAQGTGSGAGIAQAAAGTVNIGASDAYLSEGDMAAHKGLMNIALAISAQQVNYNLPGVSEHLKLNGKVLAAMYQGTIKTWDDPQIAALNPGVNLPGTAVVPLHRSDGSGDTFLFTQYLSKQDPEGWGKSPGFGTTVDFPAVPGALGENGNGGMVTGCAETPGCVAYIGISFLDQASQRGLGEAQLGNSSGNFLLPDAQSIQAAAAGFASKTPANQAISMIDGPAPDGYPIINYEYAIVNNRQKDAATAQTLQAFLHWAITDGNKASFLDQVHFQPLPPAVVKLSDALIATISSLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ARG29 GLY33 GLY34 TYR35 ASP36 TYR37 ARG71 PHE96 GLY98 SER99 D: TYR56 TYR105 SER107 TYR110 TYR111 TYR113 A: THR134 LYS136 THR137 ASP139 ASP140 PRO141 GLN142 ALA144 ALA145 PRO148 GLY149 LEU152 GLY154 ALA156 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
