Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3603 |
| PDBID: | 7DK2 |
| Chains: | DE_F |
| Organism: | Homo sapiens, Severe acute respiratory syndrome coronavirus 2 |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | MW07 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein S1 |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >7DK2_D|Chain A, D, G, J|MW07 heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVANIKQDASEKYYLDSLKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDLGILWFGDYPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: E
Mutation: NULL
| >7DK2_E|Chain B, E, H, K|MW07 light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQGISNSLAWYQQKPGKAPKLLLYAASTLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: F
Mutation: NULL
| >7DK2_F|Chain C, F, I, L|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: GLU1 GLN3 SER25 GLY26 PHE27 THR28 SER31 TYR32 TRP33 ASN50 LYS52 GLN53 GLU57 TYR59 ARG98 LEU100 GLY101 ILE102 TRP104 ASP107 E: ASN31 SER32 LYS45 TYR49 ALA50 SER52 THR53 LEU54 GLU55 SER56 GLY57 VAL58 SER60 PHE91 TYR92 SER93 THR94 ARG96 F: ARG403 ASP405 GLU406 ARG408 GLN409 GLN414 THR415 GLY416 LYS417 ASP420 TYR421 TYR449 TYR453 LEU455 PHE456 LYS458 ASN460 TYR473 ALA475 GLY476 SER477 GLU484 GLY485 PHE486 ASN487 TYR489 PHE490 GLN493 SER494 GLY496 GLN498 THR500 ASN501 GLY502 TYR505 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
