Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 358 |
| PDBID: | 2VIS |
| Chains: | BA_C |
| Organism: | Mus musculus, Influenza A virus (A/X-31(H3N2)) |
| Method: | XRD |
| Resolution (Å): | 3.25 |
| Reference: | 10.1038/nsb0298-119 |
| Antibody | |
| Antibody: | HC19 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | Yes |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >2VIS_B|Chain B|IMMUNOGLOBULIN (IGG1, LAMBDA)|Mus musculus (10090) QVQLKESGPGLVAPSQSLSITCTVSGFLLISNGVHWVRQPPGKGLEWLGVIWAGGNTNYNSALMSRVSISKDNSKSQVFLKMKSLQTDDTAMYYCARDFYDYDVFYYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVP |
Light Chain: A
Mutation: NULL
| >2VIS_A|Chain A|IMMUNOGLOBULIN (IGG1, LAMBDA)|Mus musculus (10090) QAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVLGQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLS |
Antigen
Chain: C
Mutation: T104I
| >2VIS_C|Chain C|HEMAGGLUTININ|Influenza A virus (A/X-31(H3N2)) (132504) TITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVIQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASN96 B: LEU28 ILE30 SER31 ASN32 TRP52 ALA53 GLY54 ASN56 ASN58 ASP98 TYR100 ASP101 TYR102 ASP103 PHE105 TYR107 C: THR128 GLY129 VAL130 ILE131 GLN132 ASN133 GLY134 GLY135 SER136 ASN137 SER145 TRP153 THR155 LYS156 SER157 GLY158 SER159 THR160 GLU190 SER193 LEU194 LEU226 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
