Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3576 |
| PDBID: | 7DAA |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.51 |
| Reference: | 10.1038/s41594-021-00665-8 |
| Antibody | |
| Antibody: | anti-basigin Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Isoform 2 of Basigin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7DAA_H|Chain C[auth H]|Heavy chain of antibody Fab fragment|Homo sapiens (9606) QSVEESGGRLVTPGTPLTLTCTVSGFSLSDYAMSWVRQAPGKGLEWIGIIYASGSTYYASWAKGRFTISKTSTTVDLKITSPTTEDTATYFCARYYAGSDIWGPGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: L
Mutation: NULL
| >7DAA_L|Chain B[auth L]|Light chain of antibody Fab fragment|Homo sapiens (9606) ADVVMTQTPSSVSAAVGGTVTINCQASQSISAYLAWYQQKPGQPPKLLIYDASDLASGVSSRFKGSGSGTQFTLTISDLECADAATYYCQTYYAIITYGAAFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDCTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7DAA_A|Chain A|Isoform 2 of Basigin|Homo sapiens (9606) AGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMQGSESRFFVSSSQGRSELHIENLNMEADPGQYRCQGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSSDYKDDDDK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: GLN28 SER31 ALA32 TYR33 TYR50 ASP51 ASP54 SER68 TYR92 TYR93 ALA94 ILE95 ILE96 THR97 TYR98 H: ASP30 TYR31 ALA32 TYR51 ALA52 SER53 SER55 TYR57 TYR95 TYR96 ALA97 A: VAL110 LYS111 GLU114 ILE116 GLU120 THR121 ALA122 MET123 VAL125 LYS127 SER128 PHE159 SER161 SER162 SER163 GLN164 GLY165 ARG166 GLU168 HIS170 GLU172 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
