Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3569 |
| PDBID: | 7D5Q |
| Chains: | C_A |
| Organism: | Staphylococcus aureus subsp. aureus COL, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 3.60 |
| Reference: | 10.1038/s42003-021-02357-x |
| Antibody | |
| Antibody: | 7D5Q VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | transporter from Staphylococcus aureus, NorC |
| Antigen mutation: | Yes |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >7D5Q_C|Chain C, D|ICab|Camelus dromedarius (9838) QVQLEESGGGSVQAGGSLRLSCAASGYMYSTYSTYCMGWFRQAPGKEREGVAFIKRGDHSTYYTDSVKGRFTISQDSAKNTVSLQMNNLKPEDTAIYYCAADFAHSFLLSVHSGAGQYSYWGQGTQVTVSS |
Antigen
Chain: A
Mutation: K398A
| >7D5Q_A|Chain A, B|Drug transporter, putative|Staphylococcus aureus subsp. aureus COL (93062) MNETYRGGNKLILGIVLGVITFWLFAQSLVNVVPNLQQSFGTDMGTISIAVSLTALFSGMFVVGAGGLADKIGRVKMTNIGLLLSIIGSALIIITNLPALLILGRVIQGVSAACIMPSTLAIMKTYYQGAERQRALSYWSIGSWGGSGICSLFGGAVATTMGWRWIFIFSIIVAVLSMLLIKGTPETKSEITNTHKFDVAGLIVLVVMLLSLNVVITKGAALGYTSLWFFGLIAIVIVAFFIFLNVEKKVDNPLIDFKLFENKPYTGATISNFLLNGVAGTLIVANTFVQQGLGYTALQAGYLSITYLIMVLLMIRVGEKLLQKMGSKRPMLLGTFIVVIGIALISLVFLPGIFYVISCVVGYLCFGLGLGIYATPSTDTAISNAPLDKVGVASGIYAMASSLGGAFGVAISGAVYAGAVAATSIHTGAMIALWVNVLMGIMAFIAILFAIPNDDKRVKDAKGTLVPRGSGHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: GLN5 ALA28 GLY30 TYR31 MET32 TYR33 SER34 THR35 TYR36 SER37 THR38 TYR39 ARG60 GLY61 ASP62 HIS63 SER81 ALA82 ASN84 ASP106 PHE107 ALA108 HIS109 SER110 PHE111 LEU112 LEU113 SER114 HIS116 GLY120 GLN121 SER123 A: ASN31 VAL32 VAL33 PRO34 ASN35 GLN37 GLN38 ASP43 MET44 GLY45 SER48 SER147 GLY148 SER151 LEU152 GLY155 ALA156 ALA158 THR159 LYS218 GLY219 LEU282 ILE283 VAL284 ASN286 THR287 GLN290 GLN291 GLY292 GLY294 TYR295 THR296 ALA297 LEU298 GLY301 SER304 ILE305 LEU308 VAL409 SER412 GLY413 TYR416 ALA417 VAL420 ILE425 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
