Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3565 |
| PDBID: | 7D3L |
| Chains: | HL_2 |
| Organism: | Foot-and-mouth disease virus, Bos taurus |
| Method: | EM |
| Resolution (Å): | 3.68 |
| Reference: | 10.1371/journal.ppat.1009507 |
| Antibody | |
| Antibody: | F145 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Foot-and-mouth disease virus (FMDV) O/TIBET/99 VP2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7D3L_H|Chain E[auth H]|F145 VH|Bos taurus (9913) QVQLRESGPSLVKPSQTLSLTCTASGFSLSDKAVGWVRQAPGKALEWLGSIDTGGSTGYNPGLKSRLSITKDNSKSRVSLSVSSVTTEDSATYYCTTVYHETSRTCPDGYIYDPGCGGSWVCSRLFPTDRCIVGRTTTYEWYVDAWGQGLLVTVSS |
Light Chain: L
Mutation: NULL
| >7D3L_L|Chain F[auth L]|F145 VL|Bos taurus (9913) WAQAVLTQPSSVSGSLGQRVSITCSGSSSNVGNGYVSWYQLIPGSAPRTLIYGDTSRASGVPDRISGSRSGNTATLTISSVQAEDEADYFCASAEDSSSNAVFGSGTTLTVLGDYKDDDDKGG |
Antigen
Chain: 2
Mutation: NULL
| >7D3L_2|Chain B[auth 2]|O/TIBET/99 VP2|Foot-and-mouth disease virus (12110) DKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYATAEDFVSGPNTSGLETRVVQAERFFKTHLFDWVTSDPFGRCYQLELPTDHKGVYGSLTDSYAYMRNGWDVEVTAVGNQFNGGCLLVAMVPELCSIDKRGLYQLTLFPHQFINPRTNMTAHITVPFVGVNRYDQYKVHKPWTLVVMVVAPLTVNTEGAPQIKVYANIAPTNVHVAGEFPSKE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLY115 CYS116 GLY117 GLY118 SER119 TRP120 THR128 ASP129 ARG130 CYS131 ILE132 2: VAL70 THR71 SER72 VAL189 ASN190 THR191 GLU192 GLY193 PRO195 GLN196 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
