Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3564 |
| PDBID: | 7D3K |
| Chains: | HL_2 |
| Organism: | Foot-and-mouth disease virus, Bos taurus |
| Method: | EM |
| Resolution (Å): | 3.90 |
| Reference: | 10.1371/journal.ppat.1009507 |
| Antibody | |
| Antibody: | B77 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Foot-and-mouth disease virus (FMDV) O/TIBET/99 VP2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7D3K_H|Chain E[auth H]|B77 VH|Bos taurus (9913) QVQLRESGPSLVKPSQTLSLTCTISGFSLSSYTIGWVRQAPGKALEWIGDMSNGGMPYYNPALKSRLSITKHNSKSQVRLSVSSVTPEDTATYYCAKSRYTGDGSIGLYGVDAWGQGLLITVSS |
Light Chain: L
Mutation: NULL
| >7D3K_L|Chain F[auth L]|B77 VL|Bos taurus (9913) WAQAVLTQPSSVSGSLGQRVSITCSGTYSNVGTGNYVSWFQQIPGSAPRTLIYSVTNRASGVPDRFSGSRSGHTATLTISSLQAEDEADYFCLSWQSGNTALFGSGTTLTVLGDYKDDDDKGG |
Antigen
Chain: 2
Mutation: NULL
| >7D3K_2|Chain B[auth 2]|O/TIBET/99 VP2|Foot-and-mouth disease virus (12110) DKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTYGYATAEDFVSGPNTSGLETRVVQAERFFKTHLFDWVTSDPFGRCYQLELPTDHKGVYGSLTDSYAYMRNGWDVEVTAVGNQFNGGCLLVAMVPELCSIDKRGLYQLTLFPHQFINPRTNMTAHITVPFVGVNRYDQYKVHKPWTLVVMVVAPLTVNTEGAPQIKVYANIAPTNVHVAGEFPSKE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: MET56 TYR58 THR101 GLY102 GLY104 SER105 ILE106 LEU108 VAL111 ASP112 ALA113 TRP114 L: TYR28 SER29 THR33 GLY34 TYR36 TRP95 SER97 THR100 2: HIS65 LEU66 PHE67 ASP68 VAL70 THR71 SER72 PRO74 ARG77 CYS78 TYR79 GLN80 LEU81 GLU82 LEU187 ASN190 GLU192 GLY193 PRO195 GLN196 LYS198 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
